ALIs

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LINUX Cluster Project

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Institution

  • Name: Max von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie
  • Address: Pettenkoferstraße 9 A, 80336 München
  • Project Proposal Date: 2018-08-10 14:10:35

Abstract:

In our group we are interested in the interaction of the microbiota and the host. We have established a defined mouse model composed of 12 murine isolates and we are now interested in the characterization of these isolates by whole shotgun genome sequencing. Bioinformatic analyses of the sequences are then needed to assemble, compare and study the gene content and metabolome of the 12 strains. A re-sequencing of these strains after 2 years of colonization in the mice is also ongoing. Since it was not possible to re-isolate all of them, a metagenomic approach is performed, with the consequent need of higher computational power for assembly and analyses. We are also involved in clinical study of the microbiota from human patients by 16S rRNA amplicon sequencing. Sequencing data from at least 40-50 patients are expected and a comprehensive analysis of the whole set is required to obtain a statistically significant study.