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LINUX Cluster Project

Institut für Virologie


Institution

  • Name: Institut für Virologie
  • Address: Trogerstr. 30, 81675 München
  • Project Proposal Date: 2017-07-17 16:02:32

Abstract:

Noro-Virus (NoV) is a highly mutated virus and is responsible for gastroenteritis worldwide. Long persistence of the NoV in immunocompromised and transplant patients leads the chronic infection. Currently there is no antiviral therapy or vaccine against Noro-Virus. Based on the Next-Generation-Sequencing Data (NGS) we will observe conserved and hyper viable sites in NoV. For the analysis of NGS data we need a system that can analyze, arrange and align the data and be powerful enough to reconstruct it into quasi species. Additionally 3D simulation is needed to be run, based on calculations of the molecular dynamics for a better understanding of the NoV and it's mutation and escape mechanisms.