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LINUX Cluster Project

Membran-Polymerdynamik


Institution

  • Name: Lehrstuhl für Biophysik (E22)
  • Address: James-Franck-Straße 1, 85748 Garching
  • Project Proposal Date: 2016-11-07 14:47:40

Abstract:

1.We will perform mechanical simulations to mimick the contraction of cell-populated collagen gels. Eukaryotic cells embedded in gels spontaneously contract it by two orders of magnitude, a phenomenon which we have shown to result from a purely mechanical, collective boundary effect. Crucial aspects of the phenomenology are the three-dimensional geometry and the nonlinear viscoelastic response of the gel, which call for finite-element modeling. We plan to simulate cells as active "holes" applying a constant normal stress. This ansatz embodies our conception of "dumb cells in a smart matrix" and lends itself readily to theoretical work. Whereas the active behaviour of a cell is scarcely understood, the (passive) mechanical response of the surrounding collagen gel is well known. In a first stage we will use simply constitutive equations such as Neo-Hookean materials; eventually we plan to introduce exponential energy functions in order to explore the importance of physical nonlinearities. 2.4D Visualisierung von Konfokal-Mikroskopie Daten mit der Amira Software über VNC o.ä. 3. Analysis of single molecule data with a custom Matlab routine