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LINUX Cluster Project

Simulation von Zellbewegungen


Institution

  • Name: Universität Würzburg;Zoologie I, Biozentrum
  • Address: Am Hubland, 97074 Würzburg
  • Project Proposal Date: 2017-03-07 07:44:17

Abstract:

The African trypanosome is a microswimmer with a unique morphology that migrates through the blood-brain barrier and causes the devastative sleeping sickness. The African trypanosome swims with the help of a beating filament, known as a flagellum that is firmly attached along its length to the membrane of the elongated cell body and has a free anterior part beyond the body. The trypanosome evades attack from antibodies in blood probably using the flow fields it creates during swimming. In this project, we aim to clarify the swimming dynamics of the African trypanosome within a crowded environment containing red blood cell sized particles. We model the swimming of the trypanosome in its viscous environment using the method of multi-particle collision dynamics. The spindle-shaped trypanosome cell body is modeled using a triangular network of membrane vertices connected by elastic spring and additional bending resistance potential. To conduct the simulations at a reasonable computation time, we developed an algorithm for parallel computing.