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LINUX Cluster Project

Klinisch-pneumologische Epidermiologie


  • Name: Kinderklinik und Kinderpoliklinik im Dr. von Haunerschen Kinderspital
  • Address: Lindwurmstraße 4, 80337 München
  • Project Proposal Date: 2017-07-04 12:26:50


We will study the effect of environmental and mucosal microorganisms and their metabolites on various asthma phenotypes and their interactions with the genetic background of the individuals. This will include data on microbial exposure in a sample of about 1000 children from the two German arms of the GABRIELA study. As an additional layer of complexity metabolomics data from the same samples will be assessed for three-way-interactions of microbiome, metabolome, and the underlying genome. As described in Ege & Strachan EJEP 2013, various regression models are needed for calculating the interaction estimates and p-values corrected for multiple testing. We plan to establish an R package to combine all relevant models for flexible usage in various contexts such as gene-environment interactions, SNP-SNP interactions, SNP-OTU interactions, and microbiome-metabolome associations and interactions.