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LINUX Cluster Project

Schlaganfall- und Demenzforschung


Institution

  • Name: Institut für Schlaganfall- und Demenzforschung ISD
  • Address: Feodor-Lynen-Str. 17, 81377 München
  • Project Proposal Date: 2019-05-03 09:44:29

Abstract:

Statistical genomics for Life-Sience Statistical genomics involves the integration of both statistics and genetics. Identification and interpretation of the genetic basis of human traits is the goal of population association and linkage studies. Association analysis answers the question: what are the patterns of polymorphisms that vary systematically between individuals with different disease states and could therefore represent the effects of risk-enhancing or protective alleles. Linkage analysis is focused on mapping the functionality of genes to the chromosomes, supposing that gene which is responsible for the disease is located close to its marker and they are segregating together within a pedigree. In order to increase the power of existing marker sets in genome-wide association studies, imputation algorithms are used. Linkage analysis can be performed with any number of marker loci, multiple trait loci, and multiple genomics segments with the Markov chain Monte Carlo approach. The goal of the project is to carry out the methods of statistical genomics for human population studies. ========================== AG Gökce: ru43sos2, ru24zaw2 Single cell RNA sequencing analysis. Suitability for high-performance computers or for Remote Visualization: Next Generation Sequencing technologies, and among them, single-cell RNA sequencing are cutting edge methods to decipher biological heterogeneity. ======================= ru69son2: Begründung für die Notwendigkeit eines Linux-Cluster Benutzerzugangs zu Deep Learning System Nvidia DGX-1 and OpenStack GPU VMs Verhaltenstests sind ein wichtiger Bestandteil der Forschung an der Schlaganfall-Regeneration. Diese sind meist auf Videos festgehalten und müssen manuell ausgewertet werden, was einerseits sehr viel Zeit in Anspruch nimmt und zum anderen vom Auswerter abhängige systematische Fehler verursachen kann. Mathis et. al. veröffentlichten 2018 ein öffentlich zugängliches Programm, welches vollautomatisch Videoaufnahmen von Verhaltenstests zu analysieren ermöglicht. ============================ ========== ru89liy2 UK biobank: Genetics of reserve capacity Principle investigator: Professor Dr. Michael Ewers Collaborator: Dr. Julia Neitzel, Dr. Rainer Malik Cognitive reserve is the ability to maintain cognitive abilities relatively well in the presence of pathology such as AD-related neurodegeneration. We aim to identify single-nucleotide polymorphisms (SNPs) that are associated with our previously established brain correlate of greater reserve capacity (i.e. higher left frontal cortex connectivity, Franzmeier et al., 2017, 2018; Neitzel et al., 2019). To this end, we plan to investigate imaging and genetic data of about 22,000 participants of the UK biobank. Imaging methods are preprocessing of fMRI data (mainly image registration and filtering) and connectivity analysis (correlation of timeseries data). The genetic analysis includes a genome-wide association analysis and computation of polygenetic risk scores.