ALIs

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LINUX Cluster Project

MOSAR


Institution

  • Name: Medizinische Klinik und Poliklinik IV Akutgeriatrie
  • Address: Ziemssenstr. 1, 80336 München
  • Project Proposal Date: 2018-05-07 12:31:44

Abstract:

Patients who are diagnosed with the unilateral form of primary aldosteronism (PA) will have adrenalectomy. After adrenalectomy, part of these patients with unilateral PA shows glucocorticoids insufficiency. The prediction of this occurrence by steroid profiling from mass spectrometry before surgery offers the potential for alternative non-invasive treatments or better timing of therapies. Steroid profiles in blood samples collected at five time points before surgery, namely before and after ACTH stimulation test, before and after saline infusion test and after Dexamethasone suppression test, were determined by LC-MS/MS (18 steroids at each time point). The data is analyzed by several statistical methods such as, discriminant analysis, multi-variable linear regression and decision tree analysis.