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Proposing Institution

Lehrstuhl für Biophysik
Project Manager

Dr. Till Rudack
Universitätsstr. 150
44780 Bochum
Protein recycling is vital for a wide spectrum of regulatory processes within livingcells. The executive player in this process is an ATP driven molecular machine calledthe proteasome, which both unfolds and chops superfluous proteins into smallerpieces that will be used as raw building materials for new proteins. Given its criticalrole, the proteasome is involved in multiple human diseases, and it serves as aperfect target for a plethora of different drugs, most prominently, those commonlyused in chemotherapy of cancer. Despite its substantial role in the cell’s life cycle,the proteasome is one of the last key molecular machines, which structureremained elusive for decades and its detailed atomic mechanism is stillunknown.The overarching goal is to unravel the conformational energy landscape andfemtosecond dynamics of the complex interaction clockwork of the 33 differentproteins within the functional cycle of proteasomal protein degradation.

Impressum, Conny Wendler