ZURUECK HOCH VOR INHALT SUCHEN

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Proposing Institution

Assistant Professorship Computergestützte Biokatalyse,TUM
Project Manager

Dr. Christoph Scheurer
Lichtenbergstr. 4
85748 Garching
Abstract
Heat shock protein 90 (Hsp90) is an ATP-dependent molecular chaperone involved in the folding, assembly, maturation and stabilization of a wide variety of client proteins in eukaryotes, including many kinases. The most stringent kinase client protein is the oncogenic v-Src, whereas its cellular isoform c-Src is only weakly affected by Hsp90, despite the two kinases are very similar in sequence. To address the underlying molecular mechanism for this remarkable difference, we will perform classical molecular dynamics simulations and meta-dynamics simulations to address the free landscape of the Src activation process using both the wild type and mutated variants of the Src kinase. Since the v-Src activation process is ATP-dependent, we will also perform molecular dynamics simulations on the different Src isoforms with bound ATP and with central residues in different phosphorylation states. Our project is likely to provide a basis for understand the features that render a protein Hsp90-dependent.

Impressum, Conny Wendler