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Proposing Institution

Department for Geo- and Environmental Sciences, LMU München
Project Manager

Dr. Ferdinand Jamitzky
85748 Garching
Toll-like receptors (TLRs) are a family of single membrane-spanning receptors that play a key role in the innate immune system. They are located on cell surface or compartment surface of phagocytes such as granulocytes, macrophages and dendritic cells, recognizing pathogen-ssociated microbes once they have breached physical barriers such as the skin or intestinal tract mucosa, and initiating an intracellular kinase cascade to cause an immediate defensive response. The known ligands of TLRs lipopolysaccharide, lipopeptide, CpG DNA, flagellin, dsRNA and small synthetic compounds.In this project the structure of Toll-like receptors will be predicted by using bioinformatical methods and the resulting 3-dimensional models will be numerically simulated using the NAMD and VASP software packages.

Impressum, Conny Wendler