Last modified:
13 February 2011
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Welcome to the Becker Lab!
Attention! This site will not be updated any longer. You will find the latest news for my group here.
My name is Karl-Friedrich Becker.
I am a molecular biologist and would like to introduce to you my group at the Institute of Pathology at the Technische Universität München. You will find here information about our current projects, publications, and grants. |
My group is interested in
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Epithelial-Mesenchymal-Transition (EMT) in human tumours
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Development of novel tools for diagnosis and research
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Identification of novel drug targets
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Protein analysis of clinical tissues
The principle aim of our research is the identification and characterization of molecular events involved in multistage tumorigenesis, cancer cell invasion, and metastasis for individualized treatments.
We focus on the analysis of epithelial mesenchymal transition regulators involved in down-regulating the cell adhesion molecule E-cadherin in human cancers. Very recently we established a new technique for protein analysis in clinical tissue samples. Our program linking fundamental molecular understanding to approaches that permit optimal target quantification may open new clinical avenues for a more specific diagnosis and therapy of cancer.
We succeeded in the isolation of intact, soluble and immunoreactive proteins from formalin fixed, paraffin embedded (FFPE) tissues routinely processed in our hospital. We are using reverse phase protein arrays (RPPA) to quantify known molecular markers. Our technology can also be used to identify novel disease markers in high throughput and in an automatic fashion.
We organize the 2. International Workshop on Protein Analysis of Tissues to be held in Munich from 17-18 February 2011.
My research group is connected to various national and international research programs, e.g. National Genome Research Network (NGFN), EU project “SPIDIA” (Standardisation and improvement of generic Pre-analytical tools and procedures for In-vitro DIAgnostics, www.spidia.eu), EU project „IMPACTS“ (Archive´s Tissues: improving molecular medicine research and clinical practice, www.impactsnetwork.eu). In the NGFN program, which is supported by the German Federal Ministry of Education and Research (BMBF), our group is coordinating a nationwide project entitled “FFPE tissues”.
Prof. Dr. Karl-Friedrich Becker
Institut für Pathologie
Technische Universität München
Trogerstrasse 18
D-81675 München
Germany
Tel.: ++49 89 4140 4591
email: kf.becker@lrz.tum.de
News
13 February 2011
See our latest publications:
Our next workshop
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2. International Workshop on Protein Analysis of Tissues 17.-18.2.2011 |
Recent presentations and posters
Functional Genomics - Next Generation Applications and Technologies, 03.02.2011 - 04.02.2011, DECHEMA-Haus, Frankfurt:
Lecture
Molecular profiling of protein networks in formalin-fixed and paraffin-embedded cancer tissues
Poster